Pensacola is the principal city of the Pensacola Metropolitan Area, which had an estimated 502,629 residents as of 2019. As of 2019, the population was estimated to be 52,975. Pensacola ( / ˌ p ɛ n s ə ˈ k oʊ l ə/) is the westernmost city in the Florida Panhandle, and the county seat of Escambia County, Florida.